Assessment of Anticarcinogenic Effect of Chrysin against Induced Oral Squamous Cell Carcinoma Compared to Cisplatin

Authors

1 B.D.S. (2011), M.Sc. (2019) Al-Azhar University, Assistant Lecturer of Oral Pathology -Al-Azhar University -Cairo, Egypt

2 Lecturer of Oral and Dental Pathology, Faculty of Dental Medicine for Girls, Al-Azhar University- Cairo.

3 Professor of Oral and Dental Pathology, Former Dean of the Faculty of Dental Medicine for Girls, Al-Azhar University- Cairo, Egypt, Former Dean of Faculty of Oral and Dental Medicine, Badr University- Cairo, Egypt

Abstract

Purpose: The objective of the current investigation was about to assess anticarcinogenic effect of chrysin on induced oral squamous cell carcinoma by using caspase3 as an apoptotic marker. Material and Methods: Thirty-five hamsters were used. divided into two groups. Group 1: 5 hamsters remained untreated. Group 2 (30 DMBA-received hamsters for 8 weeks) subdivided into Group 2A: 10 hamsters took DMBA and served as a positive control group. Group 2B: 10 DMBA-received hamsters for 8 weeks and treated with chrysin (50mg/kg b.w. orally/day) for another 8 weeks. Group 2C: 10 DMBA-received hamsters for 8 weeks injected with cisplatin (5mg/kg b.w.) for another 8 weeks Results: Comparing all groups according to caspase 3 expression revealed that the mean area percentage values show the statistically significant higher mean value of Caspase 3 area% in 2C group was, followed by 2B group and the lowest mean value in group 1 using ANOVA test. Conclusion: Chrysin is regarded as a promising anticarcinogenic agent against induced HBP squamous cell carcinoma.

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