The Effect of Bone Marrow Stem Cells Harvested from The Iliac Crest Versus Mandibular Ramus in Alveolar Cleft Regeneration

Document Type : Original Article

Authors

1 Oral and Maxillofacial Surgery Department, Faculty of Dental Medicine for Girls, Al-Azhar University, Egypt

2 Oro Dental Genetics Department, Human genetics and genome research institute, National Research Center Egypt

3 Future University, Dentist at the General Secretariat of Medical Centers

Abstract

Purpose : Cleft lip and palate are one of the most challenging congenital craniofacial abnormalities, that affect the children. The aim of this work was to assess clinically and radiographically the degree of alveolar cleft regeneration using Bone Marrow Stem cells harvested from mandibular Ramus versus Bone Marrow Stem cells harvested from Iliac Bone.Subjects and Methods: This comparative and prospective study was conducted on 10 patients with alveolar cleft defects. Patients with alveolar cleft defects were randomly selected and randomly divided into two equal groups: Group A: received Autologous Bone Marrow Mesenchymal Stem Cells (BMMSCs) harvested from the mandibular ramus and seeded on a collagen sponge in combination with nanohydroxyapatite. Group B: received Autologous Bone Marrow Mesenchymal Stem Cells (BMMSCs) harvested from the lilac crest and seeded on a collagen sponge in combination with nanohydroxyapatite.Results: Based on the given data, there is a significant difference The volume reduction was significantly different between both groups being better in group A compared to group B (P=0.047). Whereas there was an insignificant difference between both groups regarding the preoperative and postoperative volume area.Conclusions: The utilization of Mandibular Ramus-derived BMSCs presents numerous advantages in maxillofacial reconstruction, including reduced surgical complications, improved precision and localization, higher osteogenic potential, and lower risks of graft rejection. These benefits make it a compelling option for optimizing surgical interventions in maxillofacial reconstruction.

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