Clinical and Radiographic Evaluation of Ten Congenital Insensitivity to Pain with Anhidrosis Patients

Authors

1 Assistant Researcher of Oro-dental Genetics, Department of Oro-dental Genetics, Human genetics and genome research division, National Research Center, Cairo, Egypt

2 Professor and Head of Oral medicine, Periodontology, Diagnosis and Radiology Department, Faculty of Dental medicine for Girls, Al Azhar university, Cairo, Egypt

3 Professor of Oro-dental Genetics, Department of Oro-dental Genetics, Human genetics and genome research division, National Research Center, Cairo, Egypt

4 Researcher of Oro-dental Genetics, Department of Oro-dental Genetics, Human genetics and genome research division, National Research Center, Cairo, Egypt

5 Professor of Clinical Genetics, Clinical Genetics Department, Human Genetics and Genome Research Division, National Research Center, Cairo, Egypt

6 Professor of Oral medicine, Periodontology, Diagnosis and Radiology Department, Faculty of Dental medicine for Girls, Al Azhar university, Cairo, Egypt

Abstract

Purpose: This study was designed to introduce a standardized protocol for examination of congenital insensitivity to pain with anhidrosis patients. And also report the oro-dental manifestations in these patients. Materials and methods: In the current study, Oro-facial clinical and sensory examinations, as well as radiographic examination for ten CIPA patients were performed. Results: The Oro-dental findings were mainly missing teeth and soft tissue injuries. Radiographic examination revealed multiple congenitally missing teeth. Conclusion: A standardized protocol with Oro-facial clinical and sensory examinations, pulp sensitivity tests and radiographic examination should be considered as a primary diagnostic approach in patients with suspected Congenital insensitivity to pain with anhidrosis, instead of the more established but expensive molecular analysis and the invasive Sural nerve biopsy.

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